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KMID : 1007520210300081107
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Food Science and Biotechnology
2021 Volume.30 No. 8 p.1107 ~ p.1116
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Dietary supplementation with Ceriporia lacerata improves learning and memory in a scopolamine-induced amnesia mouse model
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Lee Su-Jin
Lim Ji-Sun
Yun Hyun-Seok
Kim Yoon-Su
Jeong Soo-Jung
Hwang Seong-Deok
Kim Jong-Won
Oh Ji-Sun
Kim Jong-Sang
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Abstract
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Ceriporia lacerata (CL) is a species of white rot fungi. In this study, we have examined the beneficial effect of CL on scopolamine-induced memory impairment in mice. A freeze-dried CL mycelial culture broth was dissolved and orally administered to scopolamine-treated C57BL/6J mice followed by behavioral tests using the Y-maze, passive avoidance, and Morris water maze tasks. CL administration at a daily dose of 200 mg/kg body weight resulted in restoration of exploration reduction and improvement of associative and spatial learning and memory impairment in scopolamine-treated mice. Concomitantly, heme oxygenase-1 was highly expressed in the hippocampal region of CL-administered mice. Moreover, the ethanolic extract of CL significantly increased the transcriptional activity of antioxidant response element and attenuated the glutamate-induced cytotoxicity in HT22 mouse hippocampal neuronal cells. These findings suggest that the CL intake can confer a beneficial effect on learning and memory presumably through protecting hippocampal neuronal cells from oxidative stress-induced damage.
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KEYWORD
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Ceriporia lacerata, Neuroprotection, Learning and memory, Hippocampal neuron, Heme oxygenase-1
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